RapamycinFungusV1, Main, Exploration, bibRecord, 000730

TORC1 and TORC2 converge to regulate the SAGA co-activator in response to nutrient availability.

Identifieur interne : 000730 ( Main/Exploration ); précédent : 000729; suivant : 000731

TORC1 and TORC2 converge to regulate the SAGA co-activator in response to nutrient availability.

Auteurs : Thomas Laboucarié [France] ; Dylane Detilleux [France] ; Ricard A. Rodriguez-Mias [États-Unis] ; Céline Faux [France] ; Yves Romeo [France] ; Mirita Franz-Wachtel [Allemagne] ; Karsten Krug [Allemagne] ; Boris Ma Ek [Allemagne] ; Judit Villén [États-Unis] ; Janni Petersen [Australie] ; Dominique Helmlinger [France]

Source :

EMBO reports [ 1469-3178 ] ; 2017.

RBID : pubmed:29079657

Descripteurs français

English descriptors

KwdEn :
- Cytoplasm (metabolism), Gene Expression Regulation, Fungal (MeSH), Mechanistic Target of Rapamycin Complex 1 (genetics), Mechanistic Target of Rapamycin Complex 2 (genetics), Mutation (MeSH), Phosphorylation (genetics), Proteomics (methods), Schizosaccharomyces (genetics), Schizosaccharomyces (metabolism), Schizosaccharomyces pombe Proteins (genetics), Schizosaccharomyces pombe Proteins (metabolism), Signal Transduction (genetics), Trans-Activators (genetics), Transcription, Genetic (MeSH).
MESH :
- chemical , genetics : Mechanistic Target of Rapamycin Complex 1, Mechanistic Target of Rapamycin Complex 2, Schizosaccharomyces pombe Proteins, Trans-Activators.
- genetics : Phosphorylation, Schizosaccharomyces, Signal Transduction.
- metabolism : Cytoplasm, Schizosaccharomyces, Schizosaccharomyces pombe Proteins.
- methods : Proteomics.
- Gene Expression Regulation, Fungal, Mutation, Transcription, Genetic.

Abstract

Gene expression regulation is essential for cells to adapt to changes in their environment. Co-activator complexes have well-established roles in transcriptional regulation, but less is known about how they sense and respond to signaling cues. We have previously shown that, in fission yeast, one such co-activator, the SAGA complex, controls gene expression and the switch from proliferation to differentiation in response to nutrient availability. Here, using a combination of genetic, biochemical, and proteomic approaches, we show that SAGA responds to nutrients through the differential phosphorylation of its Taf12 component, downstream of both the TORC1 and TORC2 pathways. Taf12 phosphorylation increases early upon starvation and is controlled by the opposing activities of the PP2A phosphatase, which is activated by TORC1, and the TORC2-activated Gad8^AKT kinase. Mutational analyses suggest that Taf12 phosphorylation prevents cells from committing to differentiation until starvation reaches a critical level. Overall, our work reveals that SAGA is a direct target of nutrient-sensing pathways and has uncovered a mechanism by which TORC1 and TORC2 converge to control gene expression and cell fate decisions.

DOI: 10.15252/embr.201744942
PubMed: 29079657
PubMed Central: PMC5709762

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000694
to stream Main, to step Curation: 000694

Le document en format XML

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<term>Mechanistic Target of Rapamycin Complex 2 (genetics)</term>
<term>Mutation (MeSH)</term>
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<term>Proteomics (methods)</term>
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<term>Schizosaccharomyces (metabolism)</term>
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<term>Schizosaccharomyces pombe Proteins (metabolism)</term>
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<term>Complexe-2 cible mécanistique de la rapamycine (génétique)</term>
<term>Cytoplasme (métabolisme)</term>
<term>Mutation (MeSH)</term>
<term>Phosphorylation (génétique)</term>
<term>Protéines de Schizosaccharomyces pombe (génétique)</term>
<term>Protéines de Schizosaccharomyces pombe (métabolisme)</term>
<term>Protéomique (méthodes)</term>
<term>Régulation de l'expression des gènes fongiques (MeSH)</term>
<term>Schizosaccharomyces (génétique)</term>
<term>Schizosaccharomyces (métabolisme)</term>
<term>Transactivateurs (génétique)</term>
<term>Transcription génétique (MeSH)</term>
<term>Transduction du signal (génétique)</term>
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<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Mechanistic Target of Rapamycin Complex 1</term>
<term>Mechanistic Target of Rapamycin Complex 2</term>
<term>Schizosaccharomyces pombe Proteins</term>
<term>Trans-Activators</term>
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<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Phosphorylation</term>
<term>Schizosaccharomyces</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Complexe-1 cible mécanistique de la rapamycine</term>
<term>Complexe-2 cible mécanistique de la rapamycine</term>
<term>Phosphorylation</term>
<term>Protéines de Schizosaccharomyces pombe</term>
<term>Schizosaccharomyces</term>
<term>Transactivateurs</term>
<term>Transduction du signal</term>
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<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cytoplasm</term>
<term>Schizosaccharomyces</term>
<term>Schizosaccharomyces pombe Proteins</term>
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<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Proteomics</term>
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<term>Protéines de Schizosaccharomyces pombe</term>
<term>Schizosaccharomyces</term>
</keywords>
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</keywords>
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<term>Mutation</term>
<term>Transcription, Genetic</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Mutation</term>
<term>Régulation de l'expression des gènes fongiques</term>
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<front><div type="abstract" xml:lang="en">Gene expression regulation is essential for cells to adapt to changes in their environment. Co-activator complexes have well-established roles in transcriptional regulation, but less is known about how they sense and respond to signaling cues. We have previously shown that, in fission yeast, one such co-activator, the SAGA complex, controls gene expression and the switch from proliferation to differentiation in response to nutrient availability. Here, using a combination of genetic, biochemical, and proteomic approaches, we show that SAGA responds to nutrients through the differential phosphorylation of its Taf12 component, downstream of both the TORC1 and TORC2 pathways. Taf12 phosphorylation increases early upon starvation and is controlled by the opposing activities of the PP2A phosphatase, which is activated by TORC1, and the TORC2-activated Gad8<sup>AKT</sup>
 kinase. Mutational analyses suggest that Taf12 phosphorylation prevents cells from committing to differentiation until starvation reaches a critical level. Overall, our work reveals that SAGA is a direct target of nutrient-sensing pathways and has uncovered a mechanism by which TORC1 and TORC2 converge to control gene expression and cell fate decisions.</div>
</front>
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<Month>07</Month>
<Day>31</Day>
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<Abstract><AbstractText>Gene expression regulation is essential for cells to adapt to changes in their environment. Co-activator complexes have well-established roles in transcriptional regulation, but less is known about how they sense and respond to signaling cues. We have previously shown that, in fission yeast, one such co-activator, the SAGA complex, controls gene expression and the switch from proliferation to differentiation in response to nutrient availability. Here, using a combination of genetic, biochemical, and proteomic approaches, we show that SAGA responds to nutrients through the differential phosphorylation of its Taf12 component, downstream of both the TORC1 and TORC2 pathways. Taf12 phosphorylation increases early upon starvation and is controlled by the opposing activities of the PP2A phosphatase, which is activated by TORC1, and the TORC2-activated Gad8<sup>AKT</sup>
 kinase. Mutational analyses suggest that Taf12 phosphorylation prevents cells from committing to differentiation until starvation reaches a critical level. Overall, our work reveals that SAGA is a direct target of nutrient-sensing pathways and has uncovered a mechanism by which TORC1 and TORC2 converge to control gene expression and cell fate decisions.</AbstractText>
<CopyrightInformation>© 2017 The Authors.</CopyrightInformation>
</Abstract>
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	Serveur d'exploration sur la rapamycine et les champignons
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TORC1 and TORC2 converge to regulate the SAGA co-activator in response to nutrient availability.

TORC1 and TORC2 converge to regulate the SAGA co-activator in response to nutrient availability.

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